Evidence for reactivation of human herpesvirus 6 in generalized lymphadenopathy in a patient with drug-induced hypersensitivity syndrome.
نویسندگان
چکیده
The present case provides direct evidence of human herpesvirus 6 reactivation in resected lymph node tissue in a patient with drug-induced hypersensitivity syndrome. This case clearly demonstrates that appropriate pathological evaluation of lymphadenopathy for drug-induced hypersensitivity syndrome, which mimics malignant lymphoma in clinical, radiological, and pathological findings, is required.
منابع مشابه
Severe hypersensitivity syndrome due to sulfasalazine associated with reactivation of human herpesvirus 6.
BACKGROUND A severe adverse reaction to sulfasalazine therapy has been associated with hypersensitivity syndrome, the clinical features of which are similar to infectious mononucleosis. No serologic evidence of viral infections has been reported with this syndrome; however, human herpesvirus 6 infection has not been specifically investigated, which could cause an infectious mononucleosislike sy...
متن کاملDrug-induced hypersensitivity syndrome (DIHS), also known as drug rash with eosinophilia and systemic symptoms (DRESS), is a severe, multi-organ, adverse reaction characterized by erythema with facial oedema,
Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Drug-induced hypersensitivity syndrome (DIHS), also known as drug rash with eosinophilia and systemic symptoms (DRESS), is a severe, multi-organ, adverse reaction characterized by erythema with facial oedema, fever, lymphadenopathy, hepatitis, and leukocytosis with eosinophilia (1–3). In more than 60% of DIHS cases, human her...
متن کاملMonomyeloid precursors in drug-induced hypersensitivity syndrome
Drug-induced hypersensitivity syndrome (DIHS), also known as drug reactions with eosinophila and systemic symptoms, has unique clinical features including fever, generalized rash, lymphadenopathy and extracutaneous organ involvements. During the disease course, human herpesvirus (HHV)-6 reactivation is frequently (60%<) observed in association with unfavorable outcomes. We recently noticed a tr...
متن کاملHuman herpesvirus 6 infection as a risk factor for the development of severe drug-induced hypersensitivity syndrome.
BACKGROUND Drug-induced hypersensitivity syndrome is characterized by a severe, potentially fatal, multiorgan hypersensitivity reaction that usually appears after prolonged exposure to certain drugs. Its delayed onset and clinical resemblance to infectious mononucleosis suggest that underlying viral infections may trigger and activate the disease in susceptible individuals receiving these drugs...
متن کاملEnhanced drug specific CD8+ T cell response at the presence of HHV-6 in DRESS patient: a case report
Background Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life-threatening multiorgan systemic reaction that includes skin rash, fever, lymphadenopathy, internal organ involvement, and leukocytosis with eosinophilia. Evidence for reactivation of human herpes virus (HHV) 6 has been seen in some DRESS patients. We present a case of allopurinolinduced DRESS syn...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of clinical microbiology
دوره 51 6 شماره
صفحات -
تاریخ انتشار 2013